FGFR inhibitors

Fibroblast growth factor receptors (FGFR) belong to a family of receptor tyrosine kinases which are involved in signal transduction associated with malignant cell proliferation, tumour progression and angiogenesis. More and more data indicate that cancers are associated with an FGFR-dependent aberrant signalling pathway; they are the result of mutation, amplification or overexpression of FGFR genes. Therapies directed against FGFR proteins constitute an attractive cancer therapy for patients with FGFR-dependent cancer, including cancers of the bladder, stomach, endometrium or lungs.