PI3Kδ kinase inhibitors

PI3K kinases are a family of lipid kinases which play a critical role in intracellular signal transduction. They take part in many cellular processes regulating the growth and proliferation of cells, their migration, as well as developing inflammatory cytokines. PI3Kδ kinase, which is part of this family, is subject to expression mainly in hematopoietic cells and is the key enzyme involved in the transmission of signals from B-cell receptor and chemokine receptors responsible for the activation, differentiation and migration of B-cells. The role of PI3Kδ kinase was confirmed to cause and maintena inflammation in conditions such as asthma, chronic obstructive pulmonary disease and rheumatoid arthritis, as well as other autoimmune diseases.