MER inhibitors

MER tyrosine kinase regulates intracellular signalling pathways and the expression of genes associated with cell survival and migration, phagocytosis of apoptotic cells, or reorganisation of the cytoskeleton. MER is overexpressed in many cancers, in both acute leukemia and in solid tumours. Inhibition of MER may have a twofold anticancer effect: on the one hand, in combination with the previously used therapies it can lead to apoptosis of cells, on the other hand it can stimulate an anticancer immune response.