5-HT6 receptor antagonists

5-HT6 receptors are located in the central nervous system and constitute an important part of the serotonin receptors. Inhibition of 5-HT6 receptors leads to increased transduction in the glutamatergic and cholinergic system and facilitates the release of dopamine and noradrenaline. Modulation of 5-HT6 receptors, due to their location and function, may be particularly important for patients suffering from various kinds of dementias with behavioural and psychological symptoms. The objective of the project is to develop a safe, chronic therapy addressed to patients suffering from these disorders.