Phosphodiesterase 10A inhibitors

Phosphodiesterase 10A (PDE10A) is an enzyme hydrolyzing cGMP and cAMP cyclic nucleotides which are universal cell transmitters. PDE10A is highly and specifically expressed in the striatal medium spiny neurons, making this protein an attractive target for pharmacological intervention for diseases caused by dysfunction of this part of the brain. Development of a PDE10A inhibitor can be particularly significant for patients suffering from schizophrenia and other psychoses, as well as Huntington’s disease, thus offering them a chance to benefit from effective treatment without the adverse effects of metabolic therapy.