The ADMET team's task is to support the Department of Medical Chemistry at every stage of project management in terms of the conduct of analytical determinations, physicochemical research as well as estimating and assessing ADMET parameters.
ADMET abbreviation is commonly used in medical chemistry and pharmacology and refers to Absorption, Distribution, Metabolism, Excretion and Toxicity for new substances with pharmacological action. These parameters, combined with efficacy of action, are critical from the point of view of whether a new chemical molecule can become a clinical candidate, and in consequence a commercial product. The ADMET team carried out analyses which are to the determine the physicochemical profile, metabolism or absorption of compounds through cell membranes, as well as other features which are of key importance to pharmacokinetics. In order to determine ADMET parameters we use various analytical techniques based mostly on chromatographic methods in combination with UV-Vis detection and mass spectrometry, as well as other spectroscopic methods (NMR, IR, UV-Vis). Furthermore, analytical work is supported with various techniques in terms of bioinformatics and chemoinformatics, which are helpful is estimating and assessing ADMET parameters.